Nodular Lymphocyte Predominant Hodgkin Lymphoma With Nodules Resembling T-Cell/Histiocyte Rich B-Cell Lymphoma Differential diagnosis between nodular lymphocyte predominant Hodgkin lymphoma and T-cell/ histiocyte rich B-cell lymphoma Short title: nodular lymphocyte predominant Hodgkin lymphoma
نویسندگان
چکیده
Ludmila Boudová, M. D., Emina Torlakovic, M. D., Jan Delabie, M.D., Peter Reimer, M.D., Beate Pfistner, Ph. D., Sabine Wiedenmann, M. D., Volker Diehl, M.D., Hans-Konrad Müller-Hermelink, M. D., Thomas Rüdiger, M. D. Department of Pathology, Charles University, Pilsen, Czech Republic, Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway, 3 Medizinische Poliklinik, University of Würzburg, Germany, German Hodgkin Lymphoma Study, Cologne, Germany, Department of Pathology, University of Würzburg, Germany
منابع مشابه
Nodular lymphocyte-predominant Hodgkin lymphoma with nodules resembling T-cell/histiocyte-rich B-cell lymphoma: differential diagnosis between nodular lymphocyte-predominant Hodgkin lymphoma and T-cell/histiocyte-rich B-cell lymphoma.
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and T-cell/histiocyte-rich B-cell lymphoma (T/HRBCL) are distinct tumors and are treated differently. They are linked by a morphologic and probably a biologic continuum, which renders the differential diagnosis difficult. To develop criteria to distinguish the entities along the morphologic continuum, we correlated the lymph node architect...
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BACKGROUND Gene expression profiling has successfully identified the prognostic significance of the host response in lymphomas. The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. The tumor cells of both lymphomas share several cha...
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Lymphomas with overlapping histological features of two distinct entities cause difficulty in classification. Their classification is of particular significance when the two alternatives require different treatment modalities. We present a diagnostically challenging case of a nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) with features of T-cell/histiocyte-rich large B-cell lymphoma (T...
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A small subset of patients with nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHLs) develop a non-Hodgkin lymphoma either concurrently or subsequently, usually T-cell/histiocyte-rich B-cell lymphomas (T/HRBCL), which are subtypes of diffuse large B-cell lymphomas (DLBCL). The standard treatment of DLBCL patients is rituximab-based chemotherapy with cyclophosphamide, adriamycin, vincristi...
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